Cancer is second among all causes of death globally, behind only
cardiovascular disease. Radiotherapy, chemotherapy, and surgery
all have their benefits, but they also come with risks, such as
fatigue, anemia, and hair loss. The search for safer alternatives
derived from plants has intensified as a result of this. Medicinal
plants containing bioactive compounds including phenols,
flavonoids, and alkaloids are utilized in traditional medicine
worldwide. These substances may have anti-cancer effects. In the
Mediterranean and neighboring areas, the squirting cucumber,
scientifically known as Ecballium elaterium (L.) A. Rich., is a
medicinal plant that belongs to the Cucurbitaceae family. Prior
studies on cancer cell lines demonstrated its anti-inflammatory,
antibacterial, and anticancer characteristics. Its anticancer efficacy
against cutaneous melanoma (B16-F1) cells has not been
explored, though, especially when using water-based extracts
from native Palestinian plants. This study delves into the
antioxidant and total phenol content as well as the anticancer
effects of E. elaterium aqueous extract.