In the ever-changing and dynamic business environment, information technology (IT) capabilities and strategic planning play a pivotal role in shaping the entrepreneurial performance of higher education institutions. This study examines the relationship between IT capabilities, strategic planning, and entrepreneurial performance in Palestinian universities during the ongoing war in Gaza (2023–2024). A descriptive-analytical quantitative approach was employed, and data were collected from 300 participants across different universities through stratified random sampling. Data were gathered between October 2023 and January 2024, during the height of the conflict, using a structured questionnaire whose measures were grounded in established theoretical frameworks. The analysis, conducted using IBM SPSS Amos v26, included descriptive statistics, confirmatory factor analysis, and structural equation modeling. Results revealed a modest but significant direct effect of IT capabilities on entrepreneurial performance (β = 0.120, p < 0.05) and a strong mediating role of strategic planning (β = 0.876, p < 0.001). The findings underscore the necessity of prioritizing IT investments and embedding proactive strategic planning to counteract severe disruptions caused by war and resource scarcity. By fostering strategic planning, the study provides practical recommendations for policymakers and university leaders, emphasizing the importance of resilience-building, diversification of funding sources, and the adoption of innovative IT-driven educational models.
