Rooftop solar PV systems has been used in the last years as one of popular renewable sources in Palestine, This paper is investigating the performance and effect of these systems on distribution network, experimental observation study of 72.8 kW roof top grid-connected photovoltaic (PV) system that is installed at engineering faculty, Nablus, Palestine (Latitude 32.2271° N, Longitude 35.2222°E), is presented. The considered system consists of 224 × 325 Wp Poly crystalline PV modules, Tripower three-phase 4X20 kW grid-connected inverter and SMA Cluster Controller& IM-10 for data acquisition and remote monitoring. Energy profile and power quality of the system was analyzed using HIOKI 9340 power quality analyzer. Total energy flow in system, variation of voltage, frequency deviation, current and voltage harmonics, and THDi and THDv at the Point of Common Coupling (PCC) and at PV system output have been studied and analyzed. Some measured values were compared with the limits set in the international standards in order to have a better understanding of the potential quality problems that this technology may introduce on the Palestinian distribution networks and to be able to solve them.