Abstract. Large numbers of emergent pollutants from pharmaceutical industries leach every day to soil and ground waters without treatment. This will lead to different health problems to both human beings and living organisms. The major problem is trying to remove this pollutant like Ibuprofen (IBP) using adsorption. In this study three adsorbents were prepared to extract the emergent drug (Ibuprofen) from aqueous solution. The three adsorbents are cellulose nanocrystalline (CNC), magnetic cellulose nanocrystalline (MNCs) and Cellulose nanocrystalline decorated with silver nanoparticles (AgNCs). The cellulose was first hydrolyzed to CNC, and then it was converted to MNCs and AgNCs. The NCs, AgNCs, showed excellent extraction efficiency toward IBP relative to MNCs. Five variables were monitored and evaluated during the extraction process: time, pH, temperature, dosage, and IBP concentrations. The adsorption process followed Langmuir isotherm model and pseudo second order. The negative ∆G° values indicates that the adsorption is favorable and spontaneous at different temperatures. The positive values of ∆H° reflect an endothermic adsorption and that the adsorption is favored at high temperature. While ΔS0 values were positive indicating the disorder at the solid/solution interface increased during adsorption process.