In vitro assessments of cytotoxic and cytostatic effect of two [Cu(dien)(N- N)]Br 2 complexes on L6, HCT, PC3 and HepG2 cancer cells
- Publication Type
- Original research
- Authors
Abstract
Two new Cu(II) complexes of type [Cu(dien)(N-N)] Br2 (dien is diethlylenetriamine, C1 complex with N-N = diethlylenetriamine and C2 complex with N-N = propyl-1,3- diamine) were made valuable and in vitro screened for both cytostatic and cytotoxic activities against four cell lines: colon cancer (HCT), liver cancer (HepG2), prostate cancer (PC3) and as control cell (L6) human muscle cell was used via MTT test. The results reflected these complexes as a promising activity antiprolifrative agent against the used cell lines indicating that C1 and C2 complexes have a high anticancer activity at non-toxic concentrations.
Journal
- Title
- ashraf sawafta
- Publisher
- Moroccan Journal of Chemistry
- Publisher Country
- Morocco
- Publication Type
- Online only
- Volume
- 7
- Year
- 2019
- Pages
- 758-764