Teucrium leucocladum is among the most used traditional medicinal plants in Palestine, which is used for the treatment of hyperglycemia and colon spasms from ancient times.tempspacetempspaceTherefore, the current investigation aimed for the first time to determine the hypoglycemic, hypolipidemic, and oxidative stress inhibitory effects of the aerial parts (stem and leaves) of T.tempspacetempspaceleucocladum hydrophilic (water) extract in streptozotocin- (STZ-) induced diabetic rats (65 mg/kg), given intraperitoneally at a dose of 100 mg/kg for 21 days.tempspacetempspaceThe rats were divided into four groups as control (C), control + T.tempspacetempspaceleucocladum extract (C + TL), diabetes (D), and diabetes + T.tempspacetempspaceleucocladum extract (D + TL).tempspacetempspaceThe antioxidant activity was analyzed using in vitro 2,2-diphenyl-1-picrylhydrazyl and in vivo methods by measuring the plasma and tissue malondialdehyde (MDA) levels using a colorimetric assay.tempspacetempspaceOn the other hand, glutathione peroxidase (GSH-Px), erythrocyte superoxide dismutase (SOD) enzyme levels, serum paraoxonase (PON), and arylesterase (ARE) enzyme activities were assessed by utilizing standard biochemical kits.tempspacetempspaceBesides, the blood glucose and serum insulin levels were assessed by a glucometer and Rat ELISA Kit, respectively.tempspacetempspaceHowever, the autoanalyzer was used to evaluate the lipid profile.tempspacetempspaceThe diabetic rat group that administered T.tempspacetempspaceleucocladum extract showed the best reduction in the tissue and plasma MDA levels …

Title

Evidence-Based Complementary and Alternative Medicine

Publisher

Hindawi

Publisher Country

United Kingdom

Indexing

Thomson Reuters

Impact Factor

1.8

Publication Type

Online only

Volume

2020

Year

2020

Pages

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