Pharmaceutical nanotechnology is an emerging technology that proved its effectiveness in decreasing the side effects and improving the therapeutic outcomes of chemotherapeutic drugs. Combretastatin A4 (CA4) is a natural potent tubulin polymerization inhibitor. However, it suffers from low water solubility with various side effects. The aim of this study was to formulate and characterize poly (lactide-co-glycolide)(PLGA) nanoparticles loaded with CA4, to assess its release kinetics and to evaluate the in vitro cytotoxic activity of the obtained nanoparticles. CA4 was synthesized according to a previous protocol. Nano-precipitation and emulsion evaporation methods were used to produce the desired drug-loaded PLGA nanoparticles. The obtained nanoparticles were characterized for shape, particle size, zeta-potential, encapsulation efficiency (EE), drug loading (DL) and release kinetics. Cytotoxicity and IC 50 of the …

Title

Materials Research Express

Publisher

IOP Publishing

Publisher Country

United Kingdom

Indexing

Thomson Reuters

Impact Factor

1.6

Publication Type

Online only

Volume

6

Year

2020

Pages

1250d7