In this study, four compounds of 2-(phenylthio)-ethyl benzoate derivatives were synthesized and evaluated for their antitumor,
antibacterial, and antifungal activities. These compounds were characterized and evaluated for their cytotoxic activity in MCF-
7-human carcinoma cells that showed a significant decrease for compounds 2a–2d in the average of G2-M phase as 8.13±1.4,
10.66±1.5, 14±2.2, and 3.66±0.8%, respectively, compared with untreated cells (21±2%; p<0.05). The data suggest that
2d compound could have an anticancer potential in the G2-M phase arrest ofMCF-7 cells ultimately leading to necrosis. The
compounds were tested for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia,
Proteus vulgaris, Enterococcus faecium, Pseudomonas aeruginosa, MRSA, and Candida albicans and showed antimicrobial
potential with MIC value average (3.125–6.25 mg/ml), compared with ampicillin (0.001–3.125 mg/ml). When the MIC of
the four compounds was compared with known references, we found that the 2a compound has the same MIC as fluconazole
(1.56 mg/ml), inhibitor of Candida growth. Moreover, 2a, 2b,, and 2d have the same MIC as ampicillin (3.125 mg/ml) for
the inhibition of S. aureus.

Title

Arabian Journal for Science and Engineering

Publisher

Springer

Publisher Country

Germany

Indexing

Thomson Reuters

Impact Factor

1.7

Publication Type

Both (Printed and Online)

Volume

46

Year

2021

Pages

5339–5344