POM Theoretical Calculations and Experimental Verification of The Antibacterial Potential of 5-Hydroxy-4-(Substituted-Amino)-2(5H)-Furanones
- Publication Type
- Original research
- Authors
- Taibi B. Hadda
- Teffaha Fergoug
- Ismail Warad
The structure and antibacterial activity of previously synthesized and tested compounds 4-amino-5-hydroxy 2(5H)-furanones 2a–h have been investigated. These compounds have previously been screened against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. Here we report results from POM analysis of their interaction with bacterial targets. The structure and governing force of the antibacterial pharmacophore site of furanones 2a–h were established on the basis of a hypothetical and semi-empirical antibacterial (Xδ+–Yδ−) pharmacophore site.
Journal
- Title
- Research on Chemical Intermediates May 2013, Volume 39, Issue 5, pp 1963-1971
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2013
- Pages
- --