Synthesis and Structural Characterization of Pd(II) Complexes Derived from Perimidine Ligand and Their in Vitro Antimicrobial Studies
- Publication Type
- Original research
- Authors
- Mohammad Azam
- Ismail Warad
- Saud I. Al-Resayes
- Nabil Alzaqri
- Mohammad Rizwan Khan
- Raghavaiah Pallepogu
- Sourabh Dwivedi
- Javed Musarrat
- Mohammad Shakir
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A novel series of Pd(II) complexes derived from 2-thiophenecarboxaldehyde and 1,8-diaminonaphthalene has been synthesized and characterized by various physico-chemical and spectroscopic techniques viz., elemental analyses, IR, UV-Vis, 1H and 13C NMR spectroscopy, and ESI-mass spectrometry. The structure of ligand, 2-(2-thienyl)-2,3-dihydro-1H-perimidine has been ascertained on the basis of single crystal X-Ray diffraction. All Pd(II) complexes together with the corresponding ligand have been evaluated for their ability to suppress the in vitro growth of microbes, E. coli, S. aureus, P. aeruginosa, Citrobacter sp., B. subtilis and S. acidaminiphila and results show that Pd(II) complexes have more significant antimicrobial activity than their corresponding ligand. Fluorescence spectroscopic measurements clearly support that both of the Pd(II) complexes show significant DNA binding with calf thymus DNA.
Journal
- Title
- Journal of Molecular Structure Volume 1047, 2013, Pages 48–54
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2013
- Pages
- --