POM as a Quick Bioinformatic Platform to Select Flavonoids and Their Metabolites as Potential and Efficient HIV-1 Integrase Inhibitors
Publication Type
Original research
Authors
  • Taibi Ben Hadda
  • Teffaha Fergoug
  • Ismail Warad
  • Vijay Masand
  • Javed Sheikh
This paper surveys the various naturally occurring flavonoids that have been isolated from different natural sources. This is the first petra/osiris/molinspiration (POM) analysis published on this topic. The present study furnishes an overview of the 32 flavonoids and anti-HIV-Integrase activity of their metabolite species. The aqueous and/or ethanol extraction of flavonoids have often been used in traditional medicine, and therefore have also been studied for their antitumor, antioxidant, antiviral, anti-algal, antimicrobial, cytotoxic and anti-inflammatory, and significant hepatoprotective and cardiovascular activity without any criteria of selection. Here, on the basis of POM analyses, a simple, economic, quick and efficient bioinformatic platform, it now becomes easy and possible to predict and optimize flavonoids bioactivity.
Journal
Title
Research on Chemical Intermediates, Volume 39, Issue 3 , pp 1227-1244
Publisher
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Publisher Country
Palestine
Publication Type
Both (Printed and Online)
Volume
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Year
2013
Pages
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