Glutathione-S-transferases (GSTs) play an important role in the detoxification of chemicals that may lead to mutagenic or cytotoxic effects. In this study, we aimed to find the effect of aqueous, methanol and ethanol extracts of both Ephedra aphylla and Ephedra foeminea on the ac-tivity of the purified sheep liver GST at the following different concentrations (0.1, 0.2, 0.4, 0.6, 0.8 and 1 mg/ml) spectrophotometrically using 1-chloro- 2, 4- dinitrobenzene (CDNB) as substrate. The obtained results revealed that all examined extracts types of Ephedra species under study ma-nifested inhibitory effect on GSTs activity at all screened concentrations. The inhibitory effect on GST activity by the alcoholic extracts of the two species under investigation at all tested concentra-tions was more than the extracts when compared to controls. Nevertheless, this was more pro-nounced in E. aphylla rather than in E. foeminea. It is worth mentioning that all the GSTs inhibito-ry effects displayed dose dependent manner under all studied extracts. On that account, the ob-tained results in this research confirms the medicinal importance of both Ephedra species under study, which provides the possibility of their use in whatever benefit human health in general and combat GST-induced resistance in drug resistant tumors in particular.

Title

Palestinian Medical and Pharmaceutical Journal

Publisher

An-Najah National University

Publisher Country

Palestine

Indexing

Scopus

Impact Factor

None

Publication Type

Online only

Volume

6

Year

2021

Pages

99-106