Abstract:
Purpose
This study examines the ability of testicular histopathology in Non-obstructive azoospermia
(NOA) to predict sperm retrieval rate (SR), quality of sperm, and success of assisted
reproductive technology.
Methods
A retrospective study recruited clinically diagnosed patients with NOA between 2007-2015.
Testicular biopsy and conventional testicular sperm extraction (TESE) were done concomitantly.
A correlation between pathological categories and SR rate, quality of sperms, and success of
intracytoplasmic sperm injection (ICSI) were studied. FSH is also measured and studied as
noninvasive and independent predictor of fertility.
Results
118 patients were recruited. Histopathological classification was hypospermatogenesis (HS) 45
(38%), maturation arrest (MA) 22(19%), Sertoli cell only syndrome (SCOS) 34 (29%), and

normal spermatogenesis (NS) 17 (14%). FSH value was above normal level in 34 (76%) of HS,
19 (86%) of MA, 32 (94%) of SCOS, and 5 (29%) of NS. Positive SR was obtained in 108
(92%) patients. The highest SR rate was seen in NS group 100% and the lowest was in SCOS 26
(77%). The worst sperm quality was found in SCOS as type C represents 46%, followed by MA
40% and HS 24%. Patients who had ICSI following TESE had a variable success rate as success
of ICSI was seen (9/15) for HS, (0/7) for MA, (5/15) for SCOS and (8/9) for NS. FSH is strongly
correlated to SR, the quality of sperm and success of ICSI as positive SR in normal FSH patients
was obtained in 28 (100%) of normal FSH, 70 (97%) of high FSH and 10 (56%) of double high
FSH (P value <001). The success of ICSI significantly correlates with FSH value as normal FSH
has 77% success ICSI rate, high FSH (52%) and double high FSH (0%) (P value <0.001)
Conclusion
Testicular biopsy and histopathology findings in NOA are strongly correlated SR rate, quality of
sperms, and success of ICSI. FSH is a strong, independent and noninvasive predictor of fertility

Conference Title

7th ACELAS INTERNATIONAL MEETING

Conference Country

Algeria

Conference Date

Sept. 21, 2023 - Sept. 23, 2023

Conference Sponsor

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Additional Info

Conference Website