Plants have been used for many healing aims since the outdated time, and to this day, many of the essential pharmaceutical dosage forms originated from herbal products. The utilization of herbal products as recognized by therapeutic agents in modern health care systems has been increasing over the past two decades. For that, the present biological screening study aimed to estimate Pelargonium graveolens four extracts from the Nablus governorate in Palestine employing reference methods. The outcomes affirmed that the four extracts of P. graveolens plant have potent antioxidant activity compared with Trolox. Actually, the aqueous extract has very potent activity, followed by acetone extract in comparison with Trolox with IC₅₀ doses of 2.29, 6.48 and 2.88 µg/ml, respectively. Besides, all the current plant four extracts have α-amylase inhibitory activity in a dose depending manner. The results showed that the aqueous extract has the potent anti-α-amylase inhibitory activity with an IC₅₀ value of 20.89±0.98 µg/ml followed by acetone extract with IC₅₀ values of 29.51 µg/ml, compared with the positive control Acarbose which has an IC₅₀ value of 28.84±1.28 µg/ml. Moreover, the aqueous P. graveolens extract has more potent antioxidant and α-amylase activity than Trolox and Acarbose, respectively. Based on the results of this study, herbal formulations with P. graveolens aqueous extract have a lot of potential for treating disorders caused by oxidative stress and diabetes.

Title

Palestinian Medical and Pharmaceutical Journal

Publisher

An-Najah National University

Publisher Country

Palestine

Indexing

Scopus

Impact Factor

0.0

Publication Type

Both (Printed and Online)

Volume

9

Year

2023

Pages

-