A Novel Ru(II) Complex Derived from Hydroxydiamine as A Potential Antitumor Agent: Synthesis and Structural Characterization
- Publication Type
- Original research
- Authors
- Mohammad Azam
- Ismail Warad
- Saud Al-Resayes
- Mohammad Shakir
- M.F. Ullah
- Aamir Ahmad
- Fazlul H. Sarkar
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A novel Ru(II)-Schiff base complex has been synthesized by the interaction of ligand, 1,3-bis{[(E)-(2-chlorophenyl)methylidene]amino}-2-propanol, L with [RuCl2(PPh3)3]. The structure of ligand, L has been determined on the basis of X-ray diffraction while the geometry of the Ru(II) complex has been ascertained by FT-IR, 1H, 13 C{1H}, 31P{1H} NMR and UV–vis studies. The in vitro antitumor activity of these compounds was assessed by examining their ability to inhibit cell proliferation against human breast and pancreatic cancer cell lines. The results show a dose-dependent anti-proliferative effect and induction of apoptotic cell death in both the cancer cell lines, thus indicating pharmacological significance of Ru(II) complex against cancer.
Journal
- Title
- Inorganic Chemistry Communications Volume 20, June 2012, Pages 252–258
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2012
- Pages
- --