The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction
- Publication Type
- Original research
- Authors
- Fulltext
- Download
Plasminogen activator inhibitor-1 (PAI-1) is linked to thrombosis and endothelial dysfunction in severe COVID-19. The +43 G>A PAI-1 and 4G/5G promoter polymorphism can influence PAI-1 expression. The 4G5G PAI-1 promoter gene polymorphism constitutes the 4G4G, 4G5G, and 5G5G genotypes. However, the impact of PAI-1 polymorphisms on disease severity or endothelial dysfunction remains unclear.
Journal
- Title
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Publisher Country
- United States of America
- Publication Type
- Prtinted only
- Volume
- --
- Year
- --
- Pages
- --