Abstract: Aim. This study investigates self-harm behaviors among Palestinian university students, utilizing both quantitative and qualitative methods. Subject and method. A sample of 528 Palestinian university students including, 174 males and 354 females’ students completed surveys measuring self-harm causes and behaviors. Results. Findings showing moderate causes (M = 3.07) and low frequency of self-harm behaviors (M = 1.95). Significant differences were found based on region, academic level, and income, with higher self-harm causes reported in rural areas, lower academic levels, and lower income brackets. Gender differences revealed that male students exhibited higher self-harm behaviors than females. Qualitative data from focus group discussions provided insights into various self-harm practices, such as skin scratching and meal-skipping, and coping mechanisms like isolation. Conclusion. The study highlights economic hardships and gender-specific pressures as key factors influencing self-harm, with males facing increased financial stress. The findings emphasize the urgent need for targeted mental health support and interventions to address self-harm behaviors among university students in Palestine