Novel counter ion exchanged in DSP-[CuX(phen)2].ClO4 complexes family and their antimicrobial/anti-inflammatory/COX-LOX evaluations
Publication Type
Original research
Authors

Using ClO4 anion, the X counter ions of the monocation [CuX (phen)2]. X complexes (X = Br, Cl, and NO3) have been nucleophilically substituted resulting in three new ClO4/X hybrids [CuX (phen)2].ClO4 salt complexes 13 for their structural and pharmacological purposes. This substitution reaction is being monitored by IR, UV–Vis, and EDX. Moreover, the desired hybrid complexes 13 were analyzed using a wide variety of analytical tools, such as EDX, X-ray, MS, FT-IR, UV–Vis., SEM, CHN-EA, and TG/DTG. Both complex 1 and complex 2 showed a high distortion square pyramid (DSP) structure centered on Cu(II) when X-ray diffraction was performed, XRD/HSA-interactions reflected the existence of several synthons mainly formed via Cph-H ….OClO3 H-bond interactions. The complexes with the most stable thermal behavior were reflected by the TG/DTG; meanwhile, only two steps of degradation were recorded. All the complexes showed high activity against eight types of bacteria strains; in most cases, the complexes were more active than the Gentamicin universal antibiotic. Additionally, the complexes' inflammation ability via cyclooxygenase (COX) and lipoxygenase (LOX) enzyme inhibitions have been recorded, and then the molecular docking using suitable enzymes was served to explain the experimental anti-inflammatory results.

Journal
Title
Journal of the Indian Chemical Society
Publisher
Elsevier
Publisher Country
Netherlands
Indexing
Thomson Reuters
Impact Factor
3.2
Publication Type
Prtinted only
Volume
102
Year
2025
Pages
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