The aim of this study is to determine whether the use of plant extracts likeEcballium elaterium andSenna italica leaf aqueous extracts helps support the activity of meropenem and vancomycin antibiotics against Staphylococcus aureusand Staphylococcus epidermis bacteria. The minimum inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were used to find out the antibacterial effect ofE. elaterium and S. italica extracts in combination with meropenem and vancomycin antibiotics by employing microbroth dilution assay and checkerboard assay. According to the obtained results, all combinations showed a synergistic effect against S. aureusexceptvancomycin and S. italicacombinations which exhibited an additive effect.Moreover, all combinations exhibited an additive effect against S.epidermisexcept vancomycin and E. elatenium, which showed a synergistic effect. In conclusion, E. elateriumandS. italicaleaf aqueous extracts have great potential as sources of antibacterial compounds against microorganisms and they can be used to treat infectious diseases caused by antibiotic-resistant microorganisms.

Title

Journal of BioScience and Biotechnology

Publisher

PLOVDIV UNIVERSITY PRESS "PAISII HILENDARSKI"

Publisher Country

Bulgaria

Publication Type

Both (Printed and Online)

Volume

13

Year

2025

Pages

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