Background: Medical students face higher rates of stress and depression compared to peers in other academic fields, with major depressive disorder (MDD) being a prevalent concern. Globally, depression affects over 264 million people, and medical students are particularly vulnerable due to academic and emotional demands. Perceived social support—gained from family, friends, and others—is a critical buffer against stress and psychological distress. High levels of support are linked to improved mental health and resilience, while low support exacerbates depressive symptoms. Methods: A cross-sectional study design was used, involving 322 medical students at An-Najah National University by using a convenience sampling method. Depression symptoms were assessed using the PHQ-8, and perceived social support was measured using the MSPSS. Statistical analysis included Pearson correlation and regression modeling. Results: The average perceived social support score (MSPSS) was 2.43 (SD = 0.717), and the average depression score (PHQ-8) was 2.25 (SD = 1.082). A significant negative correlation was found between perceived social support and depression symptoms (r = -0.279, p < 0.001), indicating that students with higher social support experienced fewer depressive symptoms. Regression analysis showed that perceived social support significantly predicted depression levels (B = -0.421, p < 0.001), accounting for 7.8% of the variance (R² = 0.078). No significant differences in depression were found based on academic year, residency, age, or sex. Conclusions: There is a significant inverse relationship between
