Objectives: This study has been done to evaluate the interaction between
ethanolic extracts of Rhus coriaria (seed), Psidium guajava (Leaf), Lawsonia
inermis (Leaf) and Sacropoterium spinosum (seed) and antimicrobial drugs
including oxytetracycline HCl, enrofloxacin, gentamicin sulphate and
sulfadimethoxine against four clinical isolates of methicillin-resistant
Staphylococcus aureus (MRSA).
Methodology: Evaluation of the interaction
between ethanolic extracts and different antimicrobial agents has been done
using well-diffusion method. Results: It showed that ethanolic extracts
increase the inhibition zones of oxytetracycline HCl, gentamicin sulphate, and
sulfadimethoxine, while combinations between these plant extracts and
enrofloxacin decrease inhibition zone.
Conclusion: This study probably suggests
the possibility of concurrent use of these antimicrobial drugs and plant
extracts in combination in treating infections caused by S. aureus strains or
at least the concomitant administration may not impair the antimicrobial
activity of these antibiotics.