Trimolecular salt Michael adducts 2a–c were synthesized in excellent
yields up to 92 % via one-pot multicomponent reactions in an aqueous medium. The
chemical structures of compounds 2a–c were characterized by X-ray single-crystal
diffraction techniques. Calculations of the density functional theory for the synthesized
compound were performed. The stability of the products was deduced by
TGA analysis. Compounds 2a–c were screened in vitro for different bio-assays such
as thymidine phosphorylase inhibition assay, urease inhibition assay, b-glucuronidase
inhibition assays and cytotoxicity against PC-3 and HeLa cell lines.