Synthesis and Anti HSV-1 Activity of 6 Substituted Pyrazole [3,4-D] Pyridazine -7-we Nucleosides
- Publication Type
- Original research
- Authors
A new series of 6-substituted N1- and N2-β-D-ribofuranosyl-pyrazolo[3,4-d]pyridazin-7(6H)-one derivs. has been prepd. in the aim to explore the structure-activity relationships and improve the antiviral activity of a series of N1- and N2-β-D-ribofuranosyl-pyrazolo[4,3-d]pyrimidin-7(6H)-one derivs. previously reported by us. The studied compds. were preliminary tested for their in vitro antiviral activity against HSV-1. Two compds. were tested and found 2-fold more active than those of the parent series. [on SciFinder(R)].
Journal
- Title
- Nucleosides & Nucleotides .17.(12),2165-2173
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 1998
- Pages
- --