Purpose: We investigated whether the prostatic calculi might influence serum PSA level.
Material and Methods: Between July 2004 and March 2005, 110 patients who underwent sextant core transrectal ultrasound (TRUS) guided prostate biopsy and diagnosed as benign prostatic hyperplasia (BPH) were included. PSA serum level determination, digital rectal examination, prostate volume measurements and prostatic calculi detection by TRUS were done for all patients. The patients were divided according to their PSA values into three groups, PSA ≥ 20 ng/ml, PSA 10-20 ng/ml and PSA < 10 ng /ml, respectively and evaluated separately.
Results: Prostatic calculi were detected in 61 of 110 patients (55.4%). There was no significant association between the presence of prostate calculi and PSA serum level (p = 0.3). There was no correlation between TPSA serum values and total or transition volume of prostate (r = 0. 05, r = 0.02). The heterogeneous echo-pattern findings at TRUS were found in 70 patients (63.6%) and there was positive correlation between the findings of TRUS and the presence of the prostatic calculi (p = 0.02).
Conclusion: The presence of prostatic calculi does not influence the serum PSA level nor the prostate volume. There was no correlation between total PSA and total and transition zone volume of the prostate.