Effect of Hemodialysis on Total, Free And Percent-Free Prostate-Specific Antigen
Publication Type
Conference Paper

Objective: To evaluate the effect of hemodialysis on serum total, free and percent-free
prostate-specific antigen (PSA) and the role of the kidney in PSA clearance,
Material and Methods: This study included 34 men with chronic renal failure (mean age
58.15, range 45-80 years) who received hemodialysis with low flux membranes. VVe
measured pre- and post hemodialysis total PSA (tPSA). free PSA (fPSA) and Hematocrit
(Htc) at one dialysis session. Additionally percent fPSA to tPSA was calculated before
and after dialysis. Hematocrit was measured before and after dialysis to find the degree
of hemoconcentration and to see whether there was a correlation between the increment
in PSA level and Hematocrit.
Results: The mean ± standard deviation for all post-dialysis tPSA levels, 1.39 ± 0.25
ng/ml, was greater than that of the pre-dialysis level, 1.19 ± 0.21 ng/ml (mean increment
= %16.81,'p = O.0001)While there was no significant increment in fPSA after dialysis
(mean increment == %7.5, P == 0,73), there was a significant increment inpercent fPSA
(mean increment = %24.49, P == 0.0009). The mean value of Hematocrit after dialysis,
36.9 ± 0.81, was greater than that before dialysis 32.15 ± 0.69 (mean increment ==
%14.77:P = 0.0001)
Conclusions: The increment in tPSA (% 16.81) was near to the increment of Htc (% 15).
So the hemoconcentration seems to be the most possible mean by which the increment
in tPSA can be explained. Thus we do not expect a renal role in the clearance of PSA,
also we believe that there is no need to adjust the values of PSA used in normal patients
for patients with chronic renal failure who are not on dialysis yet. However the increment
in Fpsa (%7.5) and percent of fPSA (%24.49) was not like that of hemococentration
(% 14,77), so we believe that the recommended reference of %fPSA for normal patients
seems not to be applicable for patients with chronic renal failure on dialysis

Conference Title
VII International Meeting of the Pan African Urological Surgeons Association
Conference Country
Conference Date
May 13, 2005 - May 13, 2005
Conference Sponsor
African Journal of Urology