Purpose: To investigate and compare the relationship between testosterone hormone and PSA levels in two different geographic regions of Turkey.
Material and Methods: The first group included 119 patients with mean age 52.73+7.53 who visited Osmaniye State Hospital for routine check-up. The second group consisted of 196 patients with mean age 50.32 +7.84 who were applied to outpatients clinics in Izmir Ataturk Teaching Hospital. Ages of the patients were less than 60 years and PSA values less than 4ng/ml. Serum testosterone levels and PSA values were determined and the association between them was evaluated and compared on the basis of the different regions.
Results: The mean values of PSA for group I and group II were 1.11+0.78 ng/ml and 1.75+10.6 ng/ml respectively (p=0.5). The mean values of testosterone levels in group I (386.4+154.6 ng/dl) and group II (383.9+170.6 ng/dl) showed no significant difference(p=0.89). There was positive correlation between age of the patients and testosterone level (r0.22,p=0.015) in group I, however in group II there was a significant negative correlation between ages and serum testosterone levels (r=-0.16, p=0.022). Serum testosterone level showed no significant correlation with PSA values in both groups (group I r=0.032,p=0.73), group II r=-0.03,p=0.65).
Conclusion: No significant difference between testosterone level and PSA values in both regions . There was no relation between testosterone serum level and TPSA values. In group II testosterone level decreases with age, however in group I, testosterone showed significant increment. Further studies are needed to confirm these preliminary results and investigate the impact of this variation on the oncologic features of prostate cancer and other urologic diseases.