Material and Methods:
Oral selective Alpha 1 blocker(doxasozin) was administered via an injector daily in rabbits (n=8) with an oral dose of0.08 mg/kg. Control rabbits
(n=4) received equivalent oral doses of vehicle control of isotonic solution. The IOP of right and left eyes of both experimental and control
rabbits were measured immediately before and 2 hours after therapy. Ten observationsfor each rabbit were recorded.
Results:
The mean values of IOP for the right eye before and after therapy were 13.6± 3.8 and 11.1±4.6mmHg respectively (P<0.002). The mean values
of IOP of the left eye before and after therapy were 13.1±4.2 and 10.1±4.4 mmHg respectively (P<0.005). The mean values of IOP for right and
left eye in control group were 15.5±3.8 and 15.4±3.1 respectively. The control group showed no significantvariation in the IOP neither in the
right nor in the left eye, P<0.7, P<0.13, respectively.
Conclusion:
Oral alpha 1 adrenergic antagonistsresult in a significant reduction in IOP in rabbit’s eye. The data may implicate potential therapeutic potential
for alpha 1 blockers for treatment of patients with high IOP. Further in vitro and vivostudies are required in a large cohort to confirm
our results.

Conference Title

23rd Turkish National Urology Meeting, 2014, Antalya

Conference Country

Turkey

Conference Date

Oct. 16, 2014 - Oct. 16, 2014

Conference Sponsor

Turkish association of urology