This study investigated the protective effect of antibodies secreted in camel milk against Salmonella typhimurium (S. typhimurium) and its potential use in oral immunotherapy to protect BALB/c mice against salmonellosis. Skimmed milk of Salmonella immunized camel was decaseined by renneting and concentrated   then were used for testing the effect of antibody dose. Mice infected with lethal dose of S. typhimurium showed a mean survival days (MSD) of 6.5 days. The dissemination of bacteria to internal organs through the blood was successively reduced in treated mice. This study proved for the first time the ability of orally administered camel antibodies derived from milk to prevent S. typhimurium infection and reduces dissemination in BALB/c mice. Furthermore, our result showed that the success of passive immunization depends on many factor such the dose and the time between exposure and the start of treatment. Elucidation of the antibody isotype responsible for the protection of mice needs further investigations.

Conference Title

DAAD Alumni workshop - Biotechnology and Agriculture in Palestine. (Hebron University and Bethlehem University, November, 30- December, 1, 2014)

Conference Country

Palestine

Conference Date

Dec. 1, 2014 - Dec. 1, 2014

Conference Sponsor

DAAD