A number of naringin based heterocyclic derivatives dioxolane and imidazolidine have been synthesized and
evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized
compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of
antibacterial activity of these compounds was determined by measuring MIC value using broth micro dilution
method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane
showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in
addition this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL,
compared with other semi synthetic derivative
Conference
Conference Title
Fourth Conference on Biotechnology research and application in Palestine