Abstract

 

Purpose:

To assess the effect of oral alpha 1 antagonists on the intraocular pressure (IOP) in rabbits eye.

Material and Methods:

Oral selective Alpha 1 blocker(doxasozin) was administered via an injector daily in rabbits (n=8) with an oral dose of0.08 mg/kg. Control rabbits (n=4) received equivalent oral doses of vehicle control of  isotonic solution. The IOP of right and left eyes of both experimental and control rabbits were measured immediately before and 2 hours after therapy. Ten observationsfor each rabbit were recorded.

Results:

The mean values of IOP for the right eye before and after therapy were 13.6± 3.8 and 11.1±4.6mmHg respectively (P<0.002). The mean values of IOP of the left eye before and after therapy were 13.1±4.2 and 10.1±4.4 mmHg respectively (P<0.005). The mean values of IOP for right and left eye in control group were 15.5±3.8 and 15.4±3.1 respectively. The control group showed no significantvariation in the IOP neither in the right nor in the left eye, P<0.7, P<0.13, respectively.

Conclusion:

Oral alpha 1 adrenergic antagonistsresult in a significant reduction in IOP in rabbit’s eye.  The data may implicate potential therapeutic potential for alpha 1 blockers for treatment of patients with high IOP. Further in vitro and vivostudies are required in a large cohort to confirm our results.

Title

International Journal of Scientific Research

Publisher

International Journal of Scientific Research

Publisher Country

India

Indexing

Scopus

Impact Factor

None

Publication Type

Prtinted only

Volume

4

Year

2016

Pages

1-4