Medication dosing errors are a significant global concern and can cause
serious medical consequences for patients. Pediatric patients are at increased risk of dosing errors
due to differences in medication pharmacodynamics and pharmacokinetics.
The aims of this study were to find the rate of medication dosing errors in hospital-
ized pediatric patients and possible associated factors.
The study was an observational cohort study including pediatric inpatients less than
16 years from three governmental hospitals from the West Bank/Palestine during one month in
2014, and sample size was 400 pediatric inpatients from these three hospitals. Pediatric patients’
medical records were reviewed. Patients’ weight, age, medical conditions, all prescribed medica-
tions, their doses and frequency were documented. Then the doses of medications were evaluated.
Among 400 patients, the medications prescribed were 949 medications, 213 of them
(22.4%) were out of the recommended range, and 160 patients (40.0%) were prescribed one or more
potentially inappropriate doses. The most common cause of hospital admission was sepsis which
presented 14.3% of cases, followed by fever (13.5%) and meningitis (10.0%). The most commonly
used medications were ampicillin in 194 cases (20.4%), ceftriaxone in 182 cases (19.2%), and
cefotaxime in 144 cases (12.0%). No significant association was found between potentially inappro-
priate doses and gender or hospital (chi-square test
-value > 0.05). The results showed that
patients with lower body weight, who had a higher number of medications and stayed in hospital
for a longer time, were more likely to have inappropriate doses