Borago officinalis plant is an important plant of high medicinal and nutritional values.  This study designed to evaluate antioxidant activity, screen the existence of phytogenic chemical compounds and to determine the total flavonoid and phenol contents of wild and cultivated Borago officinalis. Total flavonoid contents of the wild and cultivated Borago officinalis were determined by using rutin reference standard method and total phenols determined by using Folin Ciocalteu’s method while antioxidant activity evaluated by using 2, 2-diphenyl-1-picryl-hydrazyl-hydrate assay. Phytochemical analyses indicated the presence of carbohydrate, phenols, flavonoids, phytosteroids tannins and volatile oil. The total flavonoid content of the methanolic extract from the wild borage plant  was  22.4mg RU/g this value was reduced to 13.1mg RU/g for the cultivated methanolic extract as well as the total phenols contents was dropped from 5.21mg GA/g to 2.37mg GA/g methanolic extracts. Total tannins content of the wild growing borage plant was 13.7mg GA/g methanolic extract, this value was higher in the cultivated borage with 21.33mg GA/g methanolic extract. The wild leaves extract had IC₅₀ = 6.3μg/mL for wild leaves extract was closer to IC₅₀ value of Trolox (standard reference with high antioxidant activity), while the cultivated leaves extract had higher IC₅₀= 8.7μg/ml which mean lower antioxidant activity than the wild growing one. The data of this study showed  that the extracts of Borago officinalis possess antioxidant and free radical scavenging activities. Variation was clear between wild and cultivated species, these findings propose that such plant extract could be used as natural preservatives in both food and pharmaceutical industries. Therefore, more research is necessary to investigate different cultural practices on the efficiency of borage plant.

Title

Pak. J. Pharm. Sci.

Publisher

Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi

Publisher Country

Pakistan

Indexing

Thomson Reuters

Impact Factor

0.804

Publication Type

Online only

Volume

31

Year

2018

Pages

953-959