This research find out the impact of credit risk on the profitability and liquidity of commercial banks operating in Palestine. Return on Equity (ROE) is used as the indicator of profitability and cash deposit ratio as the indicator of liquidity. The study is purely based on secondary data collected from the audited financial annual reports of the commercial banks in Palestine over the years 2012 to 2016. The data is analyzed by using multiple regression. The findings highlighted that there is a significant impact of credit risk on the profitability and liquidity in Palestinian commercial banks and therefore it is advised to improve credit risk management practices in Palestinian commercial banks. Keywords: Credit risk, profitability, liquidity, banks, regressions.