Cancer remains as one of the leading causes of death in the world and
as a result there is a pressing need for the development of novel and
effective treatments. Te goal in cancer chemotherapy is to provide
cytotoxic effect to prevent tumor growth. Nowadays, drugs that
cause damage to DNA or inhibit DNA synthesis by antimetabolite
characteristics that may prevent cell division through microtubule
inhibition, inhibition of topoisomerase and inhibition of the key
tyrosine kinases are used in cancer treatment. Among other factors,
inherent and acquired resistance to treatment and the dose-limiting
toxicity caused by the narrow therapeutic window of many cancer
drugs are major obstacles in effective cancer therapy. Since clinically
useful drugs have problems with toxicity, drug resistance and
bioavailability, there is an ongoing effort to find new compounds
that may be safer or more effective. A literature survey revealed that
a number of biologically active scaffolds have important affects in
the development of antiproliferative agents. Tis article summarizes
the antiproliferative agents containing indole, pyrazole or isoxazole
backbones and combretastatin A-4 analogues with various
mechanism of actions that have published in recent years.

Title

FABAD J. Pharm. Sci

Publisher

Society of Pharmaceutical Sciences of Ankara

Publisher Country

Turkey

Indexing

Scopus

Impact Factor

None

Publication Type

Both (Printed and Online)

Volume

43

Year

2018

Pages

59-77