Vitamin C (Ascorbic acid) is a water-soluble vitamin and is highly polar compound. Humans have to get what they need of Vitamin C from food, including citrus fruits, broccoli, and tomatoes. Human bodies require vitamin C for the growth and repair of tissues in all parts of the body. Vitamin C is one of many antioxidants that block some of the damage caused by free radicals. There are some thoughts that vitamin C might help the heart and the blood vessels by preventing clots in veins and arteries, high blood pressure, and high cholesterol. Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. This mini review will focus on the role of vitamin C in these major symptoms.