The aim of this study was to develop an extemporaneous valsartan suspension
(80 mg valsartan/ 5 mL) starting from commercial tablets (80-mg/
tablet). A high-performance liquid chromatographic system was used for the
analysis and quantification of valsartan in the samples studied. Samples of
valsartan suspension for analysis were prepared as reported by the validated
high-performance liquid chromatographic method and the dissolution tests
were performed according to the U.S. Food and Drug Administration’s
method. The high-performance liquid chromatographic assay indicated that
the 80-mg/5-mL valsartan suspension was stable for 30 days when stored at
long-term and accelerated storage conditions. Valsartan release profile
showed that approximately 85% of valsartan dissolved after 10 minutes and,
accordingly, the calculation of similarity factor was not necessary. It is possible
for the pharmacist to crush valsartan 80-mg tablets and prepare a suspension
which has dosage flexibility that can be calculated according to
body-surface area, kidney, and liver functions, without affecting the chemical
stability of the active ingredient nor its dissolution profile and also have a
cost-effective dosage form.

Title

International journal of pharmaceutical compounding

Publisher

IJPC, Inc

Publisher Country

United States of America

Indexing

Scopus

Impact Factor

None

Publication Type

Both (Printed and Online)

Volume

18

Year

2014

Pages

169-174